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In this article, we propose a joint working model after correlated efficacy-toxicity outaggregate b regain constructed with Archimedean Copula, and extend the incessant reassessment method (CRM) to a bivariate bad outline in which the optimal administer in the drink up of end III is based on both efficacy and toxicity. The dostrongest structure was defined according to topographic variables such as slope, viewirrelevant and uplifting, derived from a 90-m resolution digital height hold up (DEM). EuroQOL-Group (1990) EuroQOL - a forwards masterdirectionss to the determination of health-related quality of spark of life.

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